CXCL10 and macrophage activation syndrome: MAS is associated with cytokine storm, with markedly increased production of pro-inflammatory cytokines such as TNF-α, IFN-γ, IL-1, IL-6, IL-7, and IL-18, as well as inflammatory chemokines including CXC-chemokine ligand 10 (CXCL10/IP-10), CC-chemokine ligand 2 (CCL2) and CCL3 (Merad & Martin, 2020; Schulert & Grom, 2015).