In the situation of T2DM, a particulate activation state arises, which is defined by expression of specific markers that include macrophage scavenger receptor (MSR1), ATP-binding cassette subfamily A member 1 (ABCA1), perilipin-2 (PLIN2), in addition with CD11b and CD36 [5, 39, 61]. This evidence concerns the gene PLIN2 and type 2 diabetes mellitus.