Dysregulation of HNF1α expression has been reported tobe associated with both liver cirrhosis and hepatocellular carcinoma.34 SREBF1 is involved in the synthesis of cholesteroland lipids by regulating at least 30 pertinent genes.37 The upstream regulator network, represented as a graphindicating the molecular relationships between these proteins, withthe glycoproteins identified as statistically significantly abundantin our study is highlighted in yellow (Figure 6b). This evidence concerns the gene SREBF1 and cirrhosis of liver.