Conversely, we assessed the expression levels of miR-34a-3p, miR-34a-5p, miR-335-3p and miR-335-5p in ALS-exosomes detecting an overall downregulation of all four miRNAs in exosomes released from C9orf72-, SOD1- and TARDBP-MNs compared to control exosomes (Table S1, B). Here, TARDBP is linked to amyotrophic lateral sclerosis.