Notably, the zebrafish dzip1 mutant exhibits a loss of cilia by 10 hpf [49], a time when the zebrafish eye just commences evagination, making this a useful system to ask questions regarding cilia and Hh signaling in optic cup morphogenesis, to understand how coloboma might arise in ciliopathy conditions, and how Hh signaling is affected in the zebrafish eye in the absence of cilia. This evidence concerns the gene DZIP1 and coloboma.