Using large-scale silencing data from DepMap [8], we observed a similar effect of LDLR down-regulation in both lymphoma and endometrium cholesterol auxotrophic cancer cell lines, substantially superior than the one found in cholesterol prototrophic cell lines, according to the observed CERES scores (Fig 4C, one-tailed Wilcoxon test p-value = 0.003996 for lymphoma and p-value = 0.06061 for endometrial adenocarcinoma). The gene discussed is LDLR; the disease is cancer.