AKT1 and melanoma: 1994). Magnolol could treat melanoma by the PI3K/Akt pathway (Emran et al. 2019) and attenuates prefrontal cortex oxidative stress injury in CMS mice (Cheng et al. 2018). Rosmarinic acid has been proven not only to improve doxorubicin-induced cardiotoxicity (Rahbardar et al. 2021) but also to chelate labile iron and improve DNA damage induced by H2O2 (Gerogianni et al. 2018).