For instance, Sasahira T et al reported that LEMD1 knockdown could inhibit the invasion, adhesion and migration of cancer, vascular or lymphatic vascular endothelial cells, suggesting the function of LEMD1 to be a novel tumor progressive factor and a potential marker for treatment and prognosis of oral squamous cell carcinoma [7]. Here, LEMD1 is linked to oral cavity squamous cell carcinoma.