In the SPYRAL HTN-OFF MED Pilot and Pivotal trials, ambulatory heart rate above the median (>73.5 bpm) was predictive of reduction in average daytime SBP, daytime DBP, and office SBP.69 Recently, both plasma renin activity and aldosterone levels were significantly reduced after RDN compared with sham control; higher baseline plasma renin activity was associated with a significantly greater reduction in both office and 24-hour SBP.71 The gene discussed is REN; the disease is hypertensive disorder.