,8 Mutations in PRSS56 cause nanophthalmos or autosomal-recessive posterior microphthalmos9–13; mutations in FBN1 have been linked to Marfan syndrome (MFS) and Weill–Marchesani syndrome, both of which are characterized by high myopia and ectopia lentis.14 The gene discussed is PRSS56; the disease is microphthalmia.