,8 Mutations in PRSS56 cause nanophthalmos or autosomal-recessive posterior microphthalmos9–13; mutations in FBN1 have been linked to Marfan syndrome (MFS) and Weill–Marchesani syndrome, both of which are characterized by high myopia and ectopia lentis.14 This evidence concerns the gene PRSS56 and Marfan syndrome.