–17 Furthermore, common genetic variants in these two genes have also been associated with myopia and refractive error in genome-wide association studies studies,1,2,18,19 that is, an exonic variant in PRSS56 (rs1550094-A, direction hyperopia) and an intronic variant in FBN1 (rs34539187-C, direction myopia). This evidence concerns the gene FBN1 and myopia.