TLN1 is located in focal adhesion (FA), which regulates integrin signalling and promotes metastasis in different cancers (Desiniotis and Kyprianou, 2011; Hoshino et al., 2015; Klapholz and Brown, 2017; Seguin et al., 2015), including prostate cancer (Jin et al., 2015), colon cancer (Bostanci et al., 2014), and oral squamous cell carcinoma (Lai et al., 2011). This evidence concerns the gene TLN1 and oral cavity squamous cell carcinoma.