TLN1 and Familial prostate cancer: TLN1 is located in focal adhesion (FA), which regulates integrin signalling and promotes metastasis in different cancers (Desiniotis and Kyprianou, 2011; Hoshino et al., 2015; Klapholz and Brown, 2017; Seguin et al., 2015), including prostate cancer (Jin et al., 2015), colon cancer (Bostanci et al., 2014), and oral squamous cell carcinoma (Lai et al., 2011).