Meanwhile, however, much scientific evidence has shown that involuntary tobacco smoke inhalation (ITSI) or passive smoking increases the risk of diseases such as cardiopulmonary disorders, colorectal carcinoma and respiratory diseases in vulnerable populations.20,26,31 With respect to oral health, ITSI disrupts the equilibrium between the host and environment,7,28 It is also associated with an increased expression of proinflammatory cytokines such as interleukin-1 beta (IL-1β) and IL-37 in unstimulated whole saliva (UWS),14,19,25 which contributes increased bone loss around teeth.17 The gene discussed is IL1B; the disease is respiratory system disorder.