IGFBP3 and periodontal disorder: A population-based study done in Pomerania, Germany, by Harb et al26 found that higher levels of periodontal disease were associated with low serum IGFBP-3 levels.19 Osteoclasts are considered the main culprits in inflammation-induced bone loss, as their increased numbers and hyperactivity are linked to active bone-resorption areas near the inflammatory infiltrate.