Models including interaction terms in this smaller dataset found no significant interactions between CFI type 1 RVs or VUS and CFH (P = 0.39 between CFI type 1 RVs and CFH p.Y402H homozygotes) or ARMS2 (P = 0.47 between CFI type 1 RVs and p.A69S homozygotes) on AMD risk, although interactions between CFH p.Y402H or ARMS2 p.A69S risk genotypes were significant (P = 0.021 for CFH p.Y402H homozygotes and ARMS2 p.A69S heterozygotes, P = 0.036 for CFH p.Y402H heterozygotes and ARMS2 p.A69S homozygotes, and P < 0.001 for double homozygosity). The gene discussed is CFI; the disease is age-related macular degeneration.