To test whether these findings were independent of rs10033900, a common CFI SNP which has been associated with AMD in previous genome-wide association studies (GWAS) (1), we first established the low association between rs10033900 and our selected CFI type 1 RVs (R2 = 0.0003; D′ = 0.45) and VUS (R2 = 0.0001, D′ = 0.14). This evidence concerns the gene CFI and age-related macular degeneration.