Finally, we entered the product terms of CFH p.Y402H, ARMS2 p.A69S and CFI type 1 RV or VUS genotypes into our multivariable logistic regression model (with age, gender, ethnicity, smoking status and genotype as independent variables and AMD diagnosis as the dependent variable) to explore whether the effect of each risk genotype on AMD risk would differ in the presence of other genotypes (Table 6). Here, ARMS2 is linked to age-related macular degeneration.