(3) By de‐differentiation, CRC cells convert to CSCs, and CSCs then undergo re‐differentiation/aberrant differentiation to convert into ovarian‐cancer‐like CRC cells, similar to ovarian cancer cells that are capable of secreting CA125, in which the entire cell, rather than a single gene or a set of genes, is altered. Here, MUC16 is linked to colorectal carcinoma.