AKT1 and craniosynostosis: Knowing the association between PC1 and mTOR pathways in other pathophysiologies,37, 38, 41, 42 as well as the implication of PI3K/AKT/mTOR pathway in the pathogenesis of craniosynostosis,21, 22 we aimed to detect any potential interaction of PC1 inhibition with PI3K/AKT/mTOR intracellular signalling cascade in our primary cranial suture cells.