CASP8 and carcinoma: Similar to other carcinoma, in EC various tumor suppressor gene promotors (MLH1, PTEN, p16, APC, MGMT, RASSF1, PR and CDH1) are hypermethylated, whereas oncogene promotors (BMP, CTCFL, PARP1, CASP8) are hypo- or demethylated [51].