CHMP5 and COVID-19: To enable these manufacturers to respond to the COVID-19 pandemic, we developed a COVID-19 vaccine for production in eggs, based on a recombinant Newcastle disease virus (NDV) expressing the ectodomain of a novel membrane-anchored, prefusion-stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein construct, wherein virions are purified and inactivated (NDV-HXP-S).3, 4, 5