FAP and central nervous system cancer: A recent study45 demonstrates infection and depletion of fibroblast activation protein α–positive (FAP+) cells in murine glioma upon i.t. injection of the replication-competent Ad5 ICOVIR15, which expresses the viral E1AΔ24 under regulation of a modified endogenous E1A promoter, containing eight E2F-1–binding sites and one Sp1-binding site.123