The replication-competent Ad5-Δ24-RGD has an inactivated tumor suppressor retinoblastoma protein (pRb)-binding function of E1A (the delta-24 modification) and RGD motif-containing integrin-targeting peptide (RGD-4C) inserted in the HI loop of the fiber knob domain for coxsackievirus and Ad receptor (CAR)-independent infection of cells by targeting mainly αVβ3 and αVβ5 integrins.110. This evidence concerns the gene DHTKD1 and infection.