Tumor vessels are distinct from normal vasculature in several ways as a result of chronic exposure to cytokines and growth factors secreted by cancer cells, such as VEGF, EGF, PDGF, TGF-β1, TGF-β2, fibroblast growth factor 1 and 2, IL-6, IL-8, and IL-10.95 This evidence concerns the gene TGFB1 and neoplasm.