Even up with the latest approval of the antiviral drug remdesivir, as well as the Emergency Use Licensing of monoclonal antibodies against S protein, bamlanivimab and casirimab/imdevimab, efficient and safe COVID-19 vaccines are indeed urgently needed, not only to stop the virus's spread but also to revive social and economic activities through large scale immunization. The gene discussed is PROS1; the disease is COVID-19.