Data presented in this study demonstrate: (1) The expression of UCP2 is downregulated in mouse heart 4 weeks after MI; (2) UCP2 overexpression in the heart has protective roles on myocardial fibrosis and apoptosis after MI; (3) The potential mechanism of UCP2 is involved in the microRNA-762 in upstream and DRP1-dependent mitochondrial fission downstream. This evidence concerns the gene UCP2 and myocardial infarction.