IL18 and hypohidrotic ectodermal dysplasia: Meanwhile, serum levels of pro-inflammatory cytokines including TNFα, IFNγ, IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12, and IL-18 were significantly higher (P < 0.05) in the HED group than those in the ND group (Figure 1C).