In the unadjusted model (model 1), SI was significantly associated with SMM, HGS, and gait speed, the results of which were sustained after extensive adjustment for potential confounders, including age, sex, DM, hypertension, CV disease, BMI, waist and hip circumference, hemoglobin, albumin, TCH, glucose, eGFRcys, and UPCR (model 4). The gene discussed is ALB; the disease is hypertensive disorder.