Following adjustment for confounding factors, Logistic Regression Analysis demonstrated the elevation of TIMP-1 (OR, 1.258; 95% CI, 1.005–1.574; P < 0.05) and RVD (OR, 1.224; 95% CI, 1.002–1.495; P < 0.05) as independent predictive factors for the diagnosis of PH among COPD patients. Here, TIMP1 is linked to chronic obstructive pulmonary disease.