CD34+/CD38- is a stem cell marker of both normal stem cells and LSC.53 CD34+/CD38- LSC in CML patients was found to express higher levels of CD33 compared to normal CD34+/CD38- stem cells.54 Recently, Herrmannet al. demonstrated that CD34+/CD38- CML-LSC express higher levels of CD 25, CD33, and CD 125 compared to normal BM stem cells. The gene discussed is CD34; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.