IL1RAP and chronic myelogenous leukemia, BCR-ABL1 positive: These markers were found to be downregulated after TKI administration.52 In contrast to normal stem cells, IL1RAP is a tight marker of BCR-ABL positive cells, and CD176 is a hematopoietic stem cell marker, co-expressed on CD34+/BCR-ABL+ cells of peripheral blood from CML patients.