The concentration of BMP2 and BMP4 was found to be higher in the bone marrow of CML patients in CP corresponding to normal bone marrow donors.59 BMP bind to its receptor, BMP receptor type B1 (BMPR1B), on LSC in the tumor niche and thus sustain the survival of BMPR1B+ LSC and progenitor cells. This evidence concerns the gene BMPR1B and chronic myelogenous leukemia, BCR-ABL1 positive.