Additionally, there are several ongoing or recruiting trials seeking to evaluate the potential to enhance stroke recovery of therapeutics that can influence BDNF levels in the CNS, including memantine for enhanced stroke recovery (NCT02144584) and evaluation of memantine vs. placebo on ischemic stroke outcome (NCT02535611) as well as use of donepezil in combination with transcranial direct current stimulation and intensive speech therapy (NCT04134416). The gene discussed is BDNF; the disease is Stroke.