Some DUBs regulate tumorigenesis and migration by their intrinsic oncogenic or tumor suppressor activities (UCHL1 and CYLD), or by controlling key epigenetic changes that affect cancer development (USP22), or by affecting the protein levels and/or activities of various cancer-related proteins (USP7 and USP28) (Sacco et al., 2010; Nicholson and Suresh Kumar, 2011; Wang and Dent, 2014; Harrigan et al., 2018; Xiao et al., 2019). This evidence concerns the gene CYLD and cancer.