We also found that 2 weeks of α-CGRP infusion (165 ug/kg/day) via osmotic minipumps was able to reverse L-NAME-induced hypertension, left ventricular heart weight gain, and associated increases in mRNA expression of hypertrophic markers in α-CGRP KO mice, providing evidence for the antihypertrophic effects of CGRP. The gene discussed is CALCA; the disease is hypertensive disorder.