Much like CGRP KO mice, RAMP1 KO mice develop high blood pressure (Tsujikawa et al., 2007) and knock-in or overexpression of human RAMP1 in all (Sabharwal et al., 2010) or solely neural tissues (Sabharwal et al., 2019) potentiates CGRP-dependent blood pressure reduction in AngII-induced hypertension. The gene discussed is CALCA; the disease is hypertensive disorder.