VEGFA and type 2 diabetes mellitus: Based on these previous findings, we test the hypothesis that the long-term administration of TBE and lutein supplements may have beneficial effects on the impaired retinal blood flow regulation to flicker stimulation/systemic hyperoxia, and the retinal glial activation and the overexpression of vascular endothelial growth factor (VEGF) in the type 2 diabetic mouse retina.