REN and hypertensive disorder: Hypertension is the main cause of cardiovascular diseases, and oxidative inflammation is deeply involved in the complex pathophysiology of hypertension along with sodium overloading, elevated sympathetic activity, an accelerated renin-angiotensin-aldosterone system that augments oxidative stress leading to endothelial dysfunction, vascular aging and remodeling in hypertensive patients (Reckelhoff and Romero, 2003; Guzik and Touyz, 2017).