TLR4 is highly expressed in microglia and TLR4-dependent microglial activation has been described on neurodegenerative diseases like AD or after stroke (Rojo et al., 2014; Tang and Le, 2015; Subhramanyam et al., 2019; Kolosowska et al., 2020). Here, TLR4 is linked to neurodegenerative disease.