miR-128 targets were enriched in the Simons Foundation Autism Research Initiative’s (SFARI) list of high confidence syndromic ASD genes (with a confidence score of 3 or greater), using both the entire list or restricting the list to those genes expressed in Area X. We also found that miR-128 targets were enriched in genes regulated by syndromic ASD gene chromodomain helicase DNA binding protein 8 (CHD8) at either its enhancers or promoters. The gene discussed is CHD8; the disease is autism.