NGFR and early-onset autosomal dominant Alzheimer disease: Specifically, p75NTR is involved in synaptic functions such as long-term depression of synapses (Gibon and Barker, 2017), in Alzheimer’s disease (Mufson et al., 2019; Patnaik et al., 2020), in metabolism (Baeza-Raja et al., 2016) and many other key biological processes (Roux and Barker, 2002).