MAPT and Alzheimer disease: The phosphorylated forms of PERK and eIF2α (p-PERK and p-eIF2α, respectively) are also associated with regions with AD pathology (Hoozemans et al., 2009), with p-PERK in particular concentrating in neurons with high levels of phosphorylated tau (p-tau) aggregation and markers of early NFT-induced degeneration (Unterberger et al., 2006; Hoozemans et al., 2009).