STING1 and systemic lupus erythematosus: Recent work has suggested that STING simultaneously stimulates the production of pro- and anti-inflammatory cytokines to facilitate the maintenance of gut homeostasis (Ahn et al., 2017), and studies in mouse models of systemic lupus erythematosus (SLE) have indicated STING signaling can be pro- or anti-inflammatory depending on the model (Sharma et al., 2015; Thim-uam et al., 2020; Motwani et al., 2021).