TBK1 and amyotrophic lateral sclerosis: In previous studies in the Chinese population, the frequency of LoF TBK1 mutations in sporadic ALS ± FTD was between 0 and 0.62% (none in 271 cases, one out of 162 patients, one out of 207 patients, and one out of 608 cases, respectively) (Liu et al., 2021).