A comparative study was done for isogenic derivatives cell lines of the normal HCECs with those which can mimic the mutations of three significant genes found in CRC genetic models: adenomatous polyposis coli (APC), Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and tumour protein 53 (TP53) (69). The gene discussed is KRAS; the disease is colorectal carcinoma.