Similarly, the expression of NR2F1, Vimentin, and E-cadherin were restored in HIF-1α-silenced PC cells under hypoxia condition; overexpressing NR2F1-AS1 partially reversed the effect of HIF-1α knockdown in these cells (Supplementary Fig. S9C–E). The gene discussed is NR2F1; the disease is pachyonychia congenita.