Tschorn M et al. [21] found that BDNF was a new pro-angiogenic factor, which can inhibit myocardial cell apoptosis, promote endothelial cell proliferation and migration in ischemic sites, and induce angiogenesis in ischemic tissues, and BDNF was highly expressed in atherosclerosis and ischemic heart disease. Here, BDNF is linked to atherosclerosis.