From these results above, it could thus be concluded that miR-874-3p was lowly expressed in DDP-resistant GC cell, and its upregulation could enhance the apoptosis and DDP chemosensitivity yet repress the progression of GC, which were achieved via being sponged by LINC00922 and targeting the downstream target gene GDPD5, providing the evidence regarding the roles of miR-874-3p in both the progression and drug resistance in GC altogether. This evidence concerns the gene GDPD5 and gastric cancer.