Previous discoveries have also provided a great deal of evidence concerning the involvement of GDPD5, a member of the GDPD family, in the progression of tumors and the DDP resistance in tumors by acting as the target gene of miRNAs, as well as the discussion on the interaction between GDPD5 and miR-874-3p in colorectal cancer, where GDPD5 was identified as the target gene of miR-874-3p and overexpressed GDPD5 eliminated the effects of miR-874-3p triggered on the tumor inhibition and ferroptosis of colorectal cancer cells [32,53,54]. This evidence concerns the gene GDPD5 and neoplasm.