Patients with early triple-negative breast cancer retain the benefit from standard anthracycline/taxane regimens. The use of platinum-based therapies may enhance pCR but it has not been shown to improve survival. Patients with residual disease after neoadjuvant chemotherapy and surgical management may benefit from adjuvant capecitabine. The addition of immunotherapy with checkpoint inhibitors may enhance pCR in the neoadjuvant setting, especially in those who overexpress PD-L1 or have high numbers of TILs. Here, CD274 is linked to triple-negative breast carcinoma.