AKT1 and breast carcinoma: The PI3K/AKT/mTOR signaling pathway is a complex intracellular biochemical cascade that is routinely disrupted in breast cancer and its activation favors cellular growth, proliferation, and survival [33,34]. Ipatasertib and Capivasertib are both pan-AKT inhibitors that are still under consideration for the treatment of mTNBC [35,36]. Both competitively inhibit all AKT isoforms and suppress the phosphorylation of AKT substrates that mediate cellular processes such as mitosis, apoptosis, and glucose or fatty acid metabolism.