TACSTD2 and cancer: Trop-2 is a transmembrane glycoprotein that is upregulated in all cancer types and is associated with a poorer prognosis, which makes it an attractive chemotherapeutic target [25]. Sacituzumab govitecan (SG; Trodelvy) is an ADC highly specific for trop-2 and with a high drug:antibody ratio (7:1). This ADC contains a linker protein that triggers the release of a highly potent form of irinotecan named SN-38 upon intracellular hydrolysis [26].