For example, enriched Fusobacterium nucleatum and Escherichia coli in the intestines of patients with CRC can activate the nuclear factor kappa B (NF-κB) signaling pathway and drive the infiltration of myeloid cells in the tumor, producing a pro-inflammatory environment that is conducive to the progression of colorectal tumors in Apcmin/+ mice (64, 65). The gene discussed is NFKB1; the disease is colorectal carcinoma.