CDC73 and gonorrhea: (14) showed hypermethylation of the CDC73 gene promoter in 18% (2/11) of sporadic PCs and 17% (1/6) of PAs from HPT-JT patients, all without mutation of the CDC73 gene, but not in 37 sporadic PAs, suggesting this epigenetic gene-silencing tool as an additional mechanism by which loss of the CDC73 gene expression may give rise to PCs.