Tripartite motif−containing 27 (TRIM27) is a component of the TRIM27-PI3K/Akt axis, involved in various malignant tumor processes, such as promotion of cell proliferation, inhibition of apoptosis, and facilitation of cell invasion and metastases.TRIM27 has been shown to function as an oncogene by activating epithelial-mesenchymal cell transition and its up-regulation has been associated with tumor invasion, metastasis and prognosis. The gene discussed is TRIM27; the disease is cancer.