EZH2 gene amplification at 7q36.1 locus is common in PCs (about 60% of cases), acting as an oncogene in parathyroid carcinogenesis and showing a significant over-expression of EZH2 mRNA and protein in malignant carcinomas compared with adenomas and hyperplastic parathyroid glands (9). Here, EZH2 is linked to carcinoma.