HGS and pachyonychia congenita: The putative mRNA target of miR-296-5p, the Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (HGS), which has been found to be over-expressed in PC samples with down-regulated miR-296-5p, is involved in the Wnt pathway, which is often altered in parathyroid tumors, suggesting a pro-oncogenic role of HGS up-regulation in parathyroid glands via Wnt signaling.