INS and type 2 diabetes mellitus: Administration of silymarin in patients with type 2 diabetes resulted in a significant reduction in HbA1c level, fasting plasma glucose (FPG), daily blood glucose average and glucosuria, daily insulin requirement, fasting insulin, as well as an increase in serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and HDL levels.