As per a 2 month long double blind placebo controlled trial on 25 subjects with type 2 diabetes mellitus, hydroalcoholic extract of fenugreek seed also decreased insulin resistance compared to control which was apprehended by an increase in insulin sensitivity percentage (112.9 ± 67% vs 92.2 ± 57%, respectively) and beta-cell secretion percentage (86.3 ± 32% vs 70.1 ± 52%, respectively) through HOMA-IR test (180). This evidence concerns the gene INS and Insulin resistance.