Besides, it has also been reported that the active ingredients of 5-hydroxymethylfural and acacetin in L. chinensis has been shown to promote the secretion of insulin, improve insulin resistance, and stimulate the utilization of glucose by acting on GSK3B, MAPK, INR, and dipeptidyl peptidase-4 (DPP4) (104). Here, INS is linked to Insulin resistance.