Among other isolated compounds, Momordicoside U showed moderate activity during in vitro insulin secretion property screening and 5β,19-epoxy-3 β,25-dihydroxycucurbita-6,23(E)-diene and 3 β,7 β,25-trihydroxycucurbita-5,23(E)-dien-19-al both revealed hypoglycemic activity in diabetes induced male mice models (116, 117). The gene discussed is INS; the disease is diabetes mellitus.