In another 45 days long randomized double-blinded placebo-controlled parallel clinical study on 66 subjects (age range: 20-65 years) with type 2 diabetes mellitus, 1 g daily resveratrol supplementation exhibited antihyperglycemic action by lowering the values of fasting blood glucose, hemoglobin A1c, insulin secretion, and insulin resistance compared to baseline (194). This evidence concerns the gene INS and diabetes mellitus.