Furthermore, there was a stepwise increase in renalase levels from normotension, to high-normal, to grade 1 hypertension, and finally to grade 2 hypertension (24.8, 25.6, 27.1, and 27.7 μg/mL respectively, Pfortrend < 0.001; Figure 1B). Here, RNLS is linked to hypertensive disorder.