In the multivariate binary logistic regression analysis [including LVEDD, LVEF, high-density lipoprotein cholesterol (HDL-C), NT-proBNP, AF, AMI, DM, beta-blocker, and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB)], LVEDD [odds ratio (OR): 1.05, 95% CI: 1.03–1.06], LVEF (OR: 1.14, 95% CI: 1.12–1.17), HDL-C (OR: 0.60, 95% CI: 0.38–0.94), AF (OR: 1.69, 95% CI: 1.28–2.25), and DM (OR: 1.51, 95% CI: 1.07–2.13) were detected as independent risk factors of worsening LVEF (Table 3). The gene discussed is ACE; the disease is diabetes mellitus.