CH25H and viral infectious disease: Namely, a recently published study showed that SARS-CoV-2 induces cholesterol 25-hydroxylase (25HC) both in vitro and in COVID-19 infected patients, via interferon signaling and that 25HC activation causes a depletion of accessible cholesterol on cell membrane and results in broad anti-coronavirus activity by blocking viral-cell fusion and preventing viral infection of lung epithelial cells (40).