Specifically, compared with the Sham group, levels of cleaved/pro- caspase3 were up-regulated, while that of BCL-2/Bax was down-regulated in HF rats, with the pathological changes in apoptosis-related expression attenuated (P = 0.0177; P = 0.0146) with exercise training in the HFE group (Figures 2D–F). Here, BAX is linked to hydrops fetalis.