After adjustment for age, hypertension, pulse, systolic blood pressure, total cholesterol, low-density lipoprotein, C-reactive protein, and high sensitivity C-reactive protein, multivariate ordinal logistic regression analysis showed a positive correlation between FAM9A5 and white matter hypertension on Fazekas scale (OR (95% CI) =1.842 (1.459–2.326), P < 0.001). This evidence concerns the gene CRP and hypertensive disorder.