Moreover, as a bridge connecting chronic inflammation, reactive gliosis, and degenerative diseases in the brain, FAM19A5 is overexpressed in severe depressive disorder, Alzheimer’s, Parkinson’s disease, and vascular dementia (Han et al., 2020; Li et al., 2020; Li et al., 2021; Mez et al., 2017). This evidence concerns the gene TAFA5 and neurodegenerative disease.