There was also a 2.49-fold higher ASCVD risk (95% CI [1.42–4.38], P = 0.001) in participants with an ICAM1 mRNA expression level of ≥ 3.12 than in those with an ICAM1 mRNA expression level of <3.12 (Table 5). Here, ICAM1 is linked to atherosclerosis.